[6] did not found any difference in FFM or FM, as measured with DXA, between patients and controls. presence of the two following criteria: SMI 7.25?kg/m2 and a low muscle strength (handgrip strength 30?kg) or a low muscle overall performance (timed get-up-and-go test 10?s) and cachexia by a BMI 20?kg/m2 in addition 3 from your 5 following guidelines: anorexia, fatigue, handgrip strength 30?kg, CRP 5?mg/l, SMI 7.25?kg/m2. Results Pre-sarcopenia, sarcopenia, cachexia, and osteoporosis prevalences were (50.4, 34.3, 11.9, and 16.0) respectively. Individuals experienced a mean 3?kg significant decrease in FFM and a 1?kg/m2 decrease in appendicular mass vs. healthy settings. Pre-sarcopenia, sarcopenia and cachexia were significantly connected to higher BASDAI levels and low BMD. Conclusion Our study showed Rabbit polyclonal to AK3L1 that males with AS experienced a statistically significant reduction in total and appendicular slim mass that is related to higher disease activity and significantly associated to bone loss. Electronic supplementary material The online version of this article (doi:10.1186/s12891-016-1155-z) contains supplementary material, which is available to authorized users. C-reactive protein, erythrocyte sedimentation rate, Stoke Ankylosing Spondylitis Spinal Score Individuals vs. healthy settings Table?2 shows all the body composition data for the individuals and settings. Patients experienced a mean 3?kg significant decrease in FFMI and a 1?kg/m2 decrease in SMI. There was also a significant difference in lumbar spine and total hip bone mass and T-scores. Whereas there was 16?% among the individuals that has osteoporosis (T-score below ?2.5 in either the lumbar spine or the total hip) and 50.7?% that has pre-sarcopenia according to the definition of Baumgartner (low skeletal muscle mass: SMI 7.25?kg/m2), only 3?% of the settings experienced osteoporosis and 28?% experienced pre-sarcopenia. None of our individuals had history of medical fractures. Moreover, Vertebral fractures were assessed using VFA in 33 individuals among the study population and showed mild fractures in only 3 individuals (data not demonstrated). Table Nalfurafine hydrochloride 2 Assessment of clinical variables, bone and body composition densitometric data in individuals with AS and a healthy control group body mass index, Stoke Ankylosing Spondylitis Spinal Score Determinants of pre-sarcopenia, sarcopenia and cachexia Tables?3, ?,4,4, and ?and55 show the comparison between individuals with and without pre-sarcopenia, with and without sarcopenia and with and without cachexia respectively. Globally, they showed that higher BASDAI levels, lower lumbar spine and hip BMD and T-scores and higher prevalence of osteoporosis are significantly connected to pre-sarcopenia, sarcopenia and cachexia. Table 3 Assessment of anthropometric, medical Nalfurafine hydrochloride and densitometric variables between individuals with AS with and without pre-sarcopenia (Baumgartner definition) body mass index, C-reactive protein, erythrocyte sedimentation rate, Mini Nutritional Assessment, Stoke Ankylosing Spondylitis Spinal Score Table 4 Assessment of anthropometric, medical and densitometric variables between individuals with AS with and without sarcopenia relating Nalfurafine hydrochloride to EWGSOP definition body mass index, C-reactive protein, erythrocyte sedimentation rate, Mini Nutritional Assessment, Stoke Ankylosing Spondylitis Spinal Score Table 5 Assessment of anthropometric, medical and densitometric variables between individuals with AS with and without cachexia according to the IGWS definition body mass index, bone mineral denseness, C-reactive protein, erythrocyte sedimentation rate, lumbar spine, Mini Nutritional Assessment, Stoke Ankylosing Spondylitis Spinal Score, total hip Table?6 shows regression binary analysis where pre-sarcopenia as defined by Baumgartner (SMI 7.25?kg/m2) was the dependent variable: BASDAI was the only variable significantly associated to pre-sarcopenia. Table 6 Multiple regression analysis with pre-sarcopenia as defined by Baumgartner as the dependant variable body mass index, erythrocyte sedimentation rate, lumbar spine, Mini Nutritional Assessment, Stoke Ankylosing Spondylitis Spinal Score, total hip Conversation This study showed that males with AS experienced statistically significant reduction in total (3 kgs) and appendicular slim mass. These results are concordant with those of some earlier DXA studies on the effects of AS on body composition: one.
