Cheng ZJ, Huang H, Zheng P, et al. analyzed the antibody potency and the antibody reactions induced from the booster injection in the subjects who received three vaccine doses. The study was carried out inside a multicenter collaboration and recruited 360 healthy adults aged 20C74. Participants received the 1st, second, and booster doses of inactivated Sinopharm/BBIBP COVID\19 vaccine at 0, 1, and 7 weeks. Vaccine\induced disease\specific antibody levels (SARS\COV\2\IgA/IgM/IgG) were monitored at multiple time points, surrogate disease neutralization test (sVNT), and the spatial distribution and proportion of immune cells and markers were analyzed using the CyTOF method before vaccination and a month after the second dose. The titers of SARS\CoV\2\IgA/IgM/IgG and neutralizing antibodies increased to a high level in the 1st month after receiving the second dose of Bendamustine HCl (SDX-105) vaccine and declined slowly after that. The antibody levels of SARS\CoV\2\IgG and sVNT were significantly improved at 0.5 months after the induction of the booster (p?p?p?Igf2r and manage infectious diseases. 3 , 4 Three vaccines are mainly used in China: inactivated, adenovirus vector, and recombinant protein. The inactivated vaccine is mainly through the physical or chemical method to destroy the infectious disease but at the same time keep the integrity of the antigen particles, make them shed pathogenicity, and retain antigenicity, inducing the protecting humoral immunity in the recipient. Sinovac’s CoronaVac and Sinopharm’s Beijing Bio\Institute of Biological Products Coronavirus Vaccine (BBIBP\CorV) are the two main COVID\19 inactivated vaccines homegrown and used in China. The security and performance of the two inactivated vaccines have been confirmed in preclinical tests, showing security and immunogenicity in medical tests. 5 , 6 , 7 Studies 8 , 9 have demonstrated the neutralizing antibody reaction Bendamustine HCl (SDX-105) was recognized within 14 days after the injection of the inactivated vaccine, indicating that the inactivated vaccine may be effective in inducing antibody production. Further raises in neutralizing antibody titers after the third injection indicated the need for any booster injection. With the decrease of immunity and the emergence of fresh mutations, data describing the changes in antibody dynamics with time after vaccination started to appear. Nevertheless, little information about enhancing the antibody levels and protecting effect.
