and J.D.: Methodology and data validation. Conceptualization and data analysis. D.N.: writing the original draft. All authors reviewed the original draft. Transparency declaration The authors declare no conflicts of interest. This work received no public or private funds. Acknowledgements We are grateful to the Vice-presidency and Ministry of Equality and Inclusive Guidelines of the Valencia Community, the Corporate Association of Residences and Services for People with Dependency of the Valencian Community (AERTE), the Valencia Health System nursing home departmental committees, and the staff and residents of the Piperoxan hydrochloride participant nursing homes for their collaboration in developing the ProVaVac programme. We are also grateful to Ana Berenguer, General Director of Analysis and Public Guidelines of the Presidency of the Generalitat. Ignacio Torres (Ro Hortega Contract; CM20/00090), Eliseo Albert (Juan Rods Contract; JR20/00011) and Estela Gimnez (Juan Rods Contract, JR18/00053) hold contracts funded by the Health Institute Carlos III (co-financed by the European Regional Development Fund, ERDF/FEDER). Members of the Valencian vaccine research programme (ProVaVac) study group: Burgos JS (General Directorate of Research and Healthcare Supervision, Department of Piperoxan hydrochloride Health, Valencia Government, Valencia, Spain); Meneu de Guillerna R (Vice-President Foundation Research Institute in Public Services, Valencia, Spain); Vanaclocha Luna H (General Directorate of Public Health, Department of Health, Valencia Government, Valencia, Spain); Burks DJ (The Prince Felipe Research Piperoxan hydrochloride Center-CIPF-, Valencia, Spain; Cervantes A (INCLIVA Health Research Institute, Valencia, Spain); Comas I (Biomedicine Institute of Valencia, Spanish Research Council (CSIC); Dez-Domingo J (Foundation for the promotion of health and biomedical research of the Valencian Community-FISABIO-, Valencia, Spain); Peiro S (Foundation for Piperoxan hydrochloride the promotion of health and biomedical Piperoxan hydrochloride research of the Valencian Community-FISABIO-, Valencia, Spain); Gonzlez-Candelas F (CIBER in Epidemiology and Public Health, Spain; Joint Research Unit Contamination and Public Health FISABIO-University of Valencia, Valencia, Spain; Institute for Integrative Systems Biology (I2SysBio), CSIC-University of Valencia, Valencia, Spain); Ferrer Albiach C (Fundacin Hospital Provincial de Castell); Hernndez-Aguado I (University Miguel Hernndez, Alicante, Spain); Oliver Ramrez N (DataPop Alliance); Snchez-Pay J (Preventive Medicine Support, Alicante General and University Hospital, Alicante, Spain; Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain; Vento Torres M (Instituto de Investigacin Sanitaria La Fe); Zapater Latorre E (Fundacin Hospital General Universitario de Valncia); Navarro D (Microbiology Support, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain; Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain). Notes Editor: M. Cevik Footnotes Appendix ASupplementary data to this article can be found online at https://doi.org/10.1016/j.cmi.2021.09.031. Contributor Information Valencian Vaccine Research Programme (ProVaVac) Study Group?:J.S. Burgos,9 R. Meneu de Guillerna,10 H. Vanaclocha Luna,11 D.J. Burks,12 A. Cervantes,13 I. Comas,14 J. Dez-Domingo,15 S. Peiro,16 F. Gonzlez-Candelas,17,18,19 C. Ferrer Albiach,20 I. Hernndez-Aguado,21 N. Oliver Ramrez,22 J. Snchez-Pay,23,24 M. Vento Torres,25 E. Zapater Latorre,26 and D. Navarro27,28 J.S. Burgos 9)General Directorate of Research and Healthcare Supervision, Department of Health, Valencia Government, Valencia, Spain Find Rabbit polyclonal to INPP1 articles by J.S. Burgos R. Meneu de Guillerna 10)Vice-President Foundation Research Institute in Public Services, Valencia, Spain Find articles by R. Meneu de Guillerna H. Vanaclocha Luna 11)General Directorate of Public Health, Department of Health, Valencia Government, Valencia, Spain Find articles by H. Vanaclocha Luna D.J. Burks 12)The Prince Felipe Research Center-CIPF, Valencia, Spain Find articles by D.J. Burks A. Cervantes 13)INCLIVA Health Research Institute, Valencia, Spain Find articles by A. Cervantes I. Comas 14)Biomedicine Institute of Valencia, Spanish Research Council (CSIC), Spain Find articles by I. Comas J. Dez-Domingo 15)Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO), Valencia, Spain Find articles by J. Dez-Domingo S. Peiro 16)Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO), Valencia, Spain Find articles by S. Peiro F. Gonzlez-Candelas 17)CIBER in Epidemiology and Public Health, Spain 18)Joint Research Unit Contamination and Public Health FISABIO-University of Valencia, Valencia, Spain 19)Institute for Integrative Systems Biology (I2SysBio), CSIC-University of Valencia, Valencia, Spain Find articles by F. Gonzlez-Candelas C. Ferrer Albiach 20)Fundacin Hospital Provincial de Castell, Spain Find articles by C. Ferrer Albiach I. Hernndez-Aguado 21)University Miguel Hernndez, Alicante, Spain Find articles by I. Hernndez-Aguado N. Oliver Ramrez 22)DataPop Alliance, UK Find articles by N. Oliver Ramrez J. Snchez-Pay 23)Preventive Medicine Support, Alicante General and University Hospital, Alicante, Spain 24)Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain Find articles by J. Snchez-Pay M. Vento Torres 25)Instituto de Investigacin Sanitaria La Fe, Spain Find articles by M. Vento Torres E. Zapater.