Other Oxygenases/Oxidases

May 29, 2023

Interestingly, a recent study suggested that FTY-720 functions not only by inducing S1PR1 internalization but also by inhibiting ceramide synthases, thereby decreasing cellular levels of ceramides, sphingosine, and pro-inflammatory S1P, while increasing levels of dihydrosphingosine and dihydro-S1P, effects reminiscent to those of the classical ceramide synthase inhibitor fumonisin B1 (Berdyshev et al

Interestingly, a recent study suggested that FTY-720 functions not only by inducing S1PR1 internalization but also...

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November 25, 2021

Consequently, there is debate regarding whether osimertinib would be finest reserved for second-line use, given that many patients treated with first- and second-generation EGFR TKIs up-front would be expected to be eligible to receive and benefit from subsequent osimertinib, thus prolonging the chemotherapy-free period [1, 12]

Consequently, there is debate regarding whether osimertinib would be finest reserved for second-line use, given that...

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